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Peptides for Skin: What Are Peptides & How to Use Them

Asian woman applying moisturizer to her cheek

Peptides are not new in the skincare space, but they may be new to you and your skincare routine! There is a plethora of peptide products out there, which can make it tricky to know what’s going to work for you. Peptides for skin in various forms can offer a number of benefits, including promoting the look of skin firmness and helping improve the look of the visible signs of aging, such as wrinkles and sagging skin on the lower face. Read ahead to learn all about peptides for skin and how to incorporate peptide skincare into your routine.

This article is provided for informational purposes and is not a substitute for medical advice. Always consult your dermatologist for personalized recommendations.

What Are Peptides?

Peptides are well known for their key role in skin renewal and are garnering increasing attention in skincare science. Peptides are short chains of amino acids that make up the building blocks of proteins, and their association creates an endless number of peptide combinations. They are among skin’s best allies for combatting visible signs of aging.

What Do Peptides Do for Skin?

As we age, skin’s youthful architecture slowly loses its structure due to the natural loss of collagen and elastin within the dermis. With this breakdown, we see the formation of the visible signs of aging: lines, wrinkles, volume loss, and loose, sagging skin. Anti-aging formulas that incorporate peptides can help address these visible signs of collagen loss, for more youthful-looking skin.

Are Peptides Safe?

Peptides are naturally occurring molecules that are generally safe for all skin types and can be safely incorporated into all skincare routines. Look for products with peptides that are left on the skin for a longer period of time – such as a moisturizer or serum versus a wash-off cleanser – to get the most benefits from your peptide products.

Ingredient Compatibility with Peptides

Consider the ingredient system when using (or adding) peptide products to your skincare routine. Peptides are a force of their own but work best when formulated with other powerhouse ingredients, such as hyaluronic acid and niacinamide.

Peptides and Hyaluronic Acid

As we know, peptides can help the skin appear renewed by improving the appearance of firmness, elasticity, and wrinkles. Hyaluronic acid is known to absorb several times its own weight in water, helping to smooth and re-plump the skin, complementing the smoothing effects of topical peptides. Hyaluronic acid is featured in our new Renergie HPN 300-Peptide Cream, offering deep moisturization and additional cosmetic benefits on wrinkles and skin roughness for a smooth, full-skin appearance.

Peptides and Niacinamide

Niacinamide (or vitamin B3) is a great ingredient to look out for if you experience dark spots and it’s also been shown to improve the look of a sallow skin tone. While peptides work to help restore the look of lost volume, niacinamide is known to improve the look of skin texture and tone, making this an effective duo to enliven the look of depleted skin. Our new Rénergie HPN 300-Peptide Cream contains a combination of niacinamide and over 300 unique peptides making it a great product for those who would like to improve the look of dark spots and help even skin tone while receiving anti-aging benefits.

Profile of a Caucasian woman’s face with strips of light to highlight her lower face and neck

How to Use Peptides in Your Skincare Routine

Peptides are among skin’s best allies against the visible signs of aging, including more advanced signs of aging, such as wrinkles and sagging skin on the lower face. After 30 years of research and two years in development, an exceptional number and variety of peptides were identified and formulated in our new revolutionary innovation, Rénergie HPN 300-Peptide Cream. We partnered with international scientists from different universities and start-ups to decipher those specific peptides and understand their impact on the skin. Within the thousands of peptide fractions, we identified more than 300 that are linked to the skin proteome. With the complementary effect of 300 peptides – more than we have ever brought to market in a cream format – Rénergie HPN 300-Peptide Cream can support faster and enhanced visible skin renewal.

Why 300? In the case of peptides for skin, more is more! Our biotech 300 peptides work synergistically and in complement to bring multi-faceted skincare benefits for effective and rapid results. Watch our video below to learn more about peptides at Lancôme:

Skincare Ingredient Guides

Read below our other guides to ingredients in your skincare.


Vitamin C

Hyaluronic Acid

Ferulic Acid

Salicylic Acid

Polyhydroxy Acids

Tip: use our E-Skin Expert Skin Analysis tool to help you find products for you.

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